I am broadly interested in using massive biological datasets to push our understanding of normal and abnormal cellular functions.
Recently, my work (with Erez Lieberman Aiden) has been focused on trying to understand how the human genome, which consists of roughly 2 meters of DNA when stretched out, is organized within the confines of a nucleus that is only microns wide. Understanding how this packing problem is solved in vivo is a major challenge in understanding how the cell reads information from the genome and how diverse tissue types can implement vastly different gene expression programs in order to achieve functional states. We recently published a paper where we generated extremely high resolution 3D maps of the genome across many different cell types; we found that folding is intimately linked to function. You can read more about our work here or watch a stop motion origami video we made on the topic here.