I am broadly interested in using massive biological datasets to understand how diverse types of cells utilize the same DNA to accomplish wildly different tasks.

Recently, I have been focused on understanding how cells organize 2 meters of DNA within a nucleus that is only microns wide, and how this packing helps cells shape distinct gene expression programs. My colleagues and I have:

• created extremely high resolution maps of 3D genome organization, allowing us to systematically map DNA loops connecting regulatory elements in the genome [video; press coverage on NPR's All Things Considered, NIH Director's Blog]
• discovered a new loop extrusion process that dynamically organizes DNA inside cells [video; press coverage in The Atlantic]
• developed new computational and experimental tools to predictably and reliably engineer genome folding [press coverage in TIME]
• tracked the dynamics of genome folding and gene regulation in cells over time [press coverage in Science]